克罗米酚对男性低促性腺素性功能减退症有效地

纽约（路透社健康版本）1月四日报道：据公开发表在12月出版本的《生育与后代》Magazine的一项简报反驳克罗米酮类对部分低促性腺素自闭症减退的年长者病患薄弱。来自伯明翰阿拉巴马大学的该简报的第一译者Scott J. Whitten指导教授在接受路透新闻网采访说：“病症或获得性HH病患在接受践踏性很大和比较低廉的疗程（例如注射促性腺激素类）前展开4个月的克罗米酮类早先疗程是薄弱的。”Whitten指导教授和同事研究了克罗米酮类对10名HH年长者病患（HH是导致年长者后代的鲜见因素）究竟有效。简报并称克罗米酮类疗程1年后，4名卡尔曼(宰)症病患中只有一名病患的体内剂量增加而全垂体机能减退症病患的体内缺乏症状皆并未得不到改善。无论如何，该简报反驳3名成年发病的病症HH年长者病患经过3个月克罗米酮类的疗程体内剂量有了明显增加。已确定该组病患才有两名恢复了早产。Whitten指导教授说：“除非对克罗米酮类疗程并未反应，我们一定会因为不良反应暂缓对病患使用该药物。”再一译者总结说：“因为条件有限，对HH病患促性腺激素唑和克罗米酮类的随机研究难以展开，然而利用多系列的严格同样标准对病患展开分级可能帮助进一步验证克罗米酮类恢复年长者低早产的有效性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

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总编： 张靖